                         SEQUENCE LISTING

<110>  IPSEN PHARMA S.A.S.
       DONG, Zheng Xin
 
<120>  Glucose-Dependent Insulinotropic Polypeptide Analogues

<130>  199P2/PCT2

<150>  61/200,618
<151>  2008-12-02

<150>  61/188,188
<151>  2008-08-07

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  2

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  3
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid

<400>  3

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  4
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  4

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  5
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  5

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  6
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  6

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  7
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  7

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Asn 
        35                  40              


<210>  8
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<400>  8

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Asp 
        35                  40              


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  9

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  10

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  11
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  11

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Ala 
        35                  40              


<210>  12
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  12

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Phe 
        35                  40              


<210>  13
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  13

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Thr 
        35                  40              


<210>  14
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  14

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  15
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  15

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Trp 
        35                  40              


<210>  16
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = 12-aminododecanoic acid (Ado)

<400>  16

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  17
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  17

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  18
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  modified with  N-propylsuccinimide

<400>  18

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Cys 
        35                  40          


<210>  19
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  19

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  20

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  21
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  21

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Xaa Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  22
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  22

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  23
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  23

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  24
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  24

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  25
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  25

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  26
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  26

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  27
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  27

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  28
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  28

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  29
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  29

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  30
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  30

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  31

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  32
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  32

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys His 
            20                  25                  30      


<210>  33
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  33

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  34

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  35
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  35

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  36
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<400>  36

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln Cys 
        35                  40              


<210>  37
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  37

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  38
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  38

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  39
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  39

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  40
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  40

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  41
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  41

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  42
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  42

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  43
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  43

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  44
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  44

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  45
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  45

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  46
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-20K PEG

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  46

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  47
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-20K PEG

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  47

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  48
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-20K PEG

<400>  48

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln Cys 
        35                  40              


<210>  49
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-30K PEG

<400>  49

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln Cys 
        35                  40              


<210>  50
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K PEG

<400>  50

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  51
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  51

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  52
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  52

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  53
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG

<400>  53

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  54
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  54

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  55
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  55

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  56
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<400>  56

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  57

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  58

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  59
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<400>  59

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  60

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  61
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  61

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  62
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG

<400>  62

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  63
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  63

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-20K-PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  64

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  65
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<400>  65

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  66

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  67
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)2-C(O)NH-(CH2)3-O-CH2-CH(20K 
       PEG)-CH2-20K PEG

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  67

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  68

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


